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AHR antagonist 1

CAS No. 2162982-11-6

AHR antagonist 1( —— )

Catalog No. M20332 CAS No. 2162982-11-6

AHR antagonist 1 is an aryl hydrocarbon receptor (AHR) antagonist has an IC50 of 39.9 nM in human cell line.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    AHR antagonist 1
  • Note
    Research use only, not for human use.
  • Brief Description
    AHR antagonist 1 is an aryl hydrocarbon receptor (AHR) antagonist has an IC50 of 39.9 nM in human cell line.
  • Description
    AHR antagonist 1 is an aryl hydrocarbon receptor (AHR) antagonist has an IC50 of 39.9 nM in human cell line.
  • In Vitro
    RT-PCR Cell Line:human monocytic U937 cells Concentration:1 nM-3 μM Incubation Time:Result:Regulated antagonise ligand-induced AHR gene in a dose-dependent manner.
  • In Vivo
    Animal Model:Balb/c mice (subcutaneously CT26 cells) Dosage:30 mg/kg Administration:p.o, bid Result:Significantly decreased tumors size combinated with aPD-L1.
  • Synonyms
    ——
  • Pathway
    Endocrinology/Hormones
  • Target
    AhR
  • Recptor
    AhR
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    2162982-11-6
  • Formula Weight
    401.82
  • Molecular Formula
    C20H17ClFN3O3
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:250 mg/mL (622.17 mM)
  • SMILES
    C[C@@H](CO)NC(=O)c1cc(nn(-c2cccc(F)c2)c1=O)-c1ccc(Cl)cc1
  • Chemical Name
    (S)-6-(4-chlorophenyl)-2-(3-fluorophenyl)-N-(1-hydroxypropan-2-yl)-3-oxo-23-dihydropyridazine-4-carboxamide

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Ilona Gutcher Christina Kober Lars Roeseet al.Abstract 1288: Blocking tumor-associated immune suppression with BAY-218 a novel selective aryl hydrocarbon receptor (AhR) inhibitor[J].10.1158/1538-7445.AM2019-1288 Published July 2019.
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